Two programs of which I am aware uses pywin32 (the Python for Windows extension) to access Ecco Pro's DDE interface: EccoTools and classeccodde.py. I have found that the current version of pywin32 (v 212) doesn't work, and that the newest version that does work is version 207. (BTW, you can look at all the versions of pywin32 available at sourceforge.)
The problem comes when you try to create a DDE session with the following lines:
import dde dde.CreateServer().Create('EccoSession')
If you use versions of pywin32 from v 208 up, you get a "The server could not be created" error.
Next steps: I should report this error to Mark Hammond, the author of pywin32. I wrote a message about this issue in the Ecco_Pro group to see whether others